One commonly used hyaluronan preparation is Synvisc, which is recommended for individuals with osteoarthritis in the shoulder, knee, hip or ankle who have not had success with non-surgical treatments like pain medications, physical therapy and corticosteroid injections.
Synvisc provides relief from symptoms and postpones the need for surgery by restoring the diminished synovial fluid, thus improving its lubricating properties. Optimum benefits may require a single dose or up to three separate doses of Synvisc, administered over several weeks.
Following the Synvisc injection, some patients may experience mild pain, swelling, warmth, and redness at the injection site for a maximum of 48 hours. Some individuals may also experience headaches and joint stiffness. If required, ice packs and analgesics may be used to relieve the discomfort. Any strenuous activities such as jogging or tennis should be avoided for up to a week after the injection, and should only be resumed with medical consultation.
Apart from supplementing hyaluronan in the joint, Synvisc also stimulates its production, leading to gradual relief from symptoms over the course of the injections, which may last several months.
It is essential to consult your doctor immediately if you experience a fever or if the pain and swelling persist for more than 48 hours following the injection.